ISSN : 1758-1095. In 2009 (a century later) RSTMH created a new journal called International Health to better support the growing areas of interest for our members and communities. About this journal Published since 1809, JRSM articles range from evidence-based reviews and original research papers to commentaries and personal views. Journal of the Royal Society of Medicine Vols. This site uses cookies. The trial populations did not reflect vaccination target groups due to differences in age and restrictive trial inclusion criteria. Beachler, DC, Kreimer, AR, Schiffman, M, Herrero, R, Wacholder, S, Rodriguez, AC. Author Carole Longson. The Pharmaceutical Journal is the official monthly journal of the Royal Pharmaceutical Society, with a circulation of more than 30,000* copies, making it one of the largest worldwide pharmacy member-based publications. Cuzick’s achievements relate to the application of basic science discoveries to the practice of medicine, particularly preventive medicine. About our journals. Indexed in: Science Citation Index Expanded, Scopus, CAB Abstracts, CINAHL, EMBASE, MEDLINE. At the Royal Society we take steps to ensure that researchers without funds are not disenfranchised. About Queen Mary University of LondonAt Queen Mary University of London, we believe that a diversity of ideas helps us achieve the previously unthinkable. News. The Royal Society of Medicine Collection, published by SAGE, range in scope from primary research to clinical practice, covering topics from experimental medicine to venous disease. Journal of the Royal Society of Medicine. Villa, LL, Costa, RL, Petta, CA, Andrade, RP, Paavonen, J, Iversen, OE. Supplement (DLC)sc 85007149 (OCoLC)10461570: Material Type: Document, Internet resource: Document Type: Internet Resource, Computer File, Journal / Magazine / Newspaper: All Authors / Contributors: For further information or a copy of the paper please contact: Rosalind Dewar Media Office, Royal Society of Medicine DL: +44 (0) 1580 764713 M: +44 (0) 7785 182732 E: media@rsm.ac.uk. JRSM - Journal of the Royal Society of Medicine. The researchers found that the trials were not designed to detect cervical cancer, which takes decades to develop. Human Papillomaviruses. It is still uncertain whether human papillomavirus (HPV) vaccination prevents cervical cancer as trials were not designed to detect this outcome, which takes decades to develop. Previous title: Journal of the Royal Asiatic Society of Great Britain and Ireland (New Series) (1864 - 1990) ... Prehospital and Disaster Medicine. The analysis, published by the Journal of the Royal Society of Medicine, assessed 12 published Phase 2 and 3 randomised controlled efficacy trials of the HPV vaccines … Munoz, N, Kjaer, SK, Sigurdsson, K, Iversen, OE, Hernandez-Avila, M, Wheeler, CM. Shareable Link. Volume 90. *Publisher statement - Royal Pharmaceutical Society membership data - … Sara Miller McCune founded SAGE Publishing in 1965 to support the dissemination of usable knowledge and educate a global community. You can be signed in via any or all of the methods shown below at the same time. Simply select your manager software from the list below and click on download. Simply select your manager software from the list below and click on download. Our analysis shows the trials themselves generated significant uncertainties undermining claims of efficacy in these data. Primary Health Care Research & Development. Lean Library can solve it. Abstract. Human papillomavirus (HPV) vaccines as an option for preventing cervical malignancies: (how) effective and safe? The analysis, carried out by researchers at Newcastle University and Queen Mary University of London, revealed many methodological problems in the design of the Phase 2 and 3 efficacy trials, leading to uncertainty regarding understanding the effectiveness of HPV vaccination. LATEST NEWS. SAGE remains majority owned by our founder and after her lifetime will become owned by a charitable trust that secures the company’s continued independence. By . Women in the trials were followed up for six years or less, apart from one trial extension to just under nine years. Natural history of cervical intraepithelial neoplasia: a critical review, CIN2 is a much less reproducible and less valid diagnosis than CIN3: results from a histological review of population-based cervical samples, The cervical cancer epidemic that screening has prevented in the UK, Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16–26 years: a randomised, double-blind trial, Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors, The Cochrane HPV vaccine review was incomplete and ignored important evidence of bias, Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial, Sustained efficacy up to 4.5 years of a bivalent L1 virus-like particle vaccine against human papillomavirus types 16 and 18: follow-up from a randomised control trial, Sustained efficacy and immunogenicity of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine: analysis of a randomised placebo-controlled trial up to 6.4 years, Sustained efficacy and immunogenicity of the HPV-16/18 AS04-adjuvanted vaccine up to 7.3 years in young adult women, Sustained immunogenicity and efficacy of the HPV-16/18 AS04-adjuvanted vaccine: up to 8.4 years of follow-up, Sustained efficacy, immunogenicity, and safety of the HPV-16/18 AS04-adjuvanted vaccine: final analysis of a long-term follow-up study up to 9.4 years post-vaccination, Efficacy of human papillomavirus 16/18 AS04-adjuvanted vaccine in Japanese women aged 20 to 25 years: interim analysis of a phase 2 double-blind, randomized, controlled trial, Efficacy of human papillomavirus type 16/18 AS04-adjuvanted vaccine in Japanese women aged 20 to 25 years: final analysis of a phase 2 double-blind, randomized controlled trial, Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blind, randomised controlled trial, Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women, Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial, Cross-protective efficacy of HPV-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by non-vaccine oncogenic HPV types: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial, Occurrence of vaccine and non-vaccine human papillomavirus types in adolescent Finnish females 4 years post-vaccination, Efficacy of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine in women aged 15–25 years with and without serological evidence of previous exposure to HPV-16/18, Efficacy of human papillomavirus 16 and 18 (HPV-16/18) AS04-adjuvanted vaccine against cervical infection and precancer in young women: final event-driven analysis of the randomized, double-blind PATRICIA trial, Post hoc analysis of the PATRICIA randomized trial of the efficacy of human papillomavirus type 16 (HPV-16)/HPV-18 AS04-adjuvanted vaccine against incident and persistent infection with nonvaccine oncogenic HPV types using an alternative multiplex type-specific PCR assay for HPV DNA, Prevention of persistent human papillomavirus infection by an HPV16/18 vaccine: a community-based randomized clinical trial in Guanacaste, Costa Rica, Proof-of-principle evaluation of the efficacy of fewer than three doses of a bivalent HPV16/18 vaccine, Impact of human papillomavirus vaccination on cervical cytology screening, colposcopy, and treatment, Efficacy of the HPV-16/18 vaccine: final according to protocol results from the blinded phase of the randomized Costa Rica HPV-16/18 vaccine trial, Impact of human papillomavirus (HPV) 16 and 18 vaccination on prevalent infections and rates of cervical lesions after excisional treatment, Multisite HPV16/18 vaccine efficacy against cervical, anal, and oral HPV infection, Efficacy, safety, and immunogenicity of the human papillomavirus 16/18 AS04-adjuvanted vaccine in women older than 25 years: 4-year interim follow-up of the phase 3, double-blind, randomised controlled VIVIANE study, Efficacy, safety, and immunogenicity of the human papillomavirus 16/18 AS04-adjuvanted vaccine in women older than 25 years: 7-year follow-up of the phase 3, double-blind, randomised controlled VIVIANE study, Efficacy, immunogenicity and safety of the HPV-16/18 AS04-adjuvanted vaccine in healthy Chinese women aged 18–25 years: results from a randomized controlled trial, Efficacy, immunogenicity, and safety of the HPV-16/18 AS04-adjuvanted vaccine in Chinese women aged 18–25 years: event-triggered analysis of a randomized controlled trial, Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial, High sustained efficacy of a prophylactic quadrivalent human papillomavirus types 6/11/16/18 L1 virus-like particle vaccine through 5 years of follow-up, Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases, Prophylactic efficacy of a quadrivalent human papillomavirus (HPV) vaccine in women with virological evidence of HPV infection, Safety, immunogenicity, and efficacy of quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine in women aged 24–45 years: a randomised, double-blind trial, End-of-study safety, immunogenicity, and efficacy of quadrivalent HPV (types 6, 11, 16, 18) recombinant vaccine in adult women 24–45 years of age, Efficacy of quadrivalent human papillomavirus (types 6, 11, 16 and 18) vaccine (GARDASIL) in Japanese women aged 18–26 years, Efficacy of quadrivalent human papillomavirus vaccine against persistent infection and genital disease in Chinese women: a randomized, placebo-controlled trial with 78-month follow-up, Clinical course of untreated cervical intraepithelial neoplasia grade 2 under active surveillance: systematic review and meta-analysis, Impact of human papillomavirus (HPV)-6/11/16/18 vaccine on all HPV-associated genital diseases in young women, Efficacy and other milestones for human papillomavirus vaccine introduction, Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update, Long-term absolute risk of cervical intraepithelial neoplasia grade 3 or worse following human papillomavirus infection: role of persistence, HPV vaccines – a review of the first decade, Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions, Safety and immunogenicity of human papillomavirus-16/18 AS04-adjuvanted vaccine: a randomized trial in 10–25-year-old HIV-seronegative African girls and young women, The impact of quadrivalent human papillomavirus (HPV; types 6, 11, 16, and 18) L1 virus-like particle vaccine on infection and disease due to oncogenic nonvaccine HPV types in generally HPV-naive women aged 16–26 years, Serotype replacement in disease after pneumococcal vaccination, The 2010 global proficiency study of human papillomavirus genotyping in vaccinology, The serological response to papillomaviruses, Reduction of low- and high-grade cervical abnormalities associated with high uptake of the HPV bivalent vaccine in Scotland, Prevalence of cervical disease at age 20 after immunisation with bivalent HPV vaccine at age 12–13 in Scotland: retrospective population study, Trends in the sexual behaviour of 15-year olds in Scotland: 2002–14, HPV vaccination programs have not been shown to be cost-effective in countries with comprehensive Pap screening and surgery. Journal of the Royal Society of Medicine (Online) Identifiers. Resource information Archival Status. Network WHOHPL . Contact us if you experience any difficulty logging in. Royal Society of Medicine Today at 11:00 PM Organised by # RSMPsyc Section Integrity in research: lessons from ... the British Journal of Psychiatry 25 Feb ⌚ 6pm GMT ⭐ CPD Watch live or on-demand (T&Cs apply) Visit the RSM # Psychiatry Section homepage and scroll down to view upcoming webinars https://rsm.ac/38rpz5L See More Subject: HEALTH SCIENCES. Analysis, published in the Journal of the Royal Society of Medicine, reports that the HPV vaccine may be less effective than previously thought.. Dr Gillian Knight, Associate Dean, School of Engineering & Applied Science, Aston University. View or download all content the institution has subscribed to. By continuing to browse This, too, means that the trials may have overestimated the efficacy of the vaccine, again because some of the lesions would have regressed spontaneously.”. Journal of the Royal Society of Medicine. Supplement (Online) (DLC) 2010252215 (OCoLC)60624363 Journal of the Royal Society of Medicine. doi: 10.1258/jrsm.2012.12k018. Volume 106, Issue 12. pp. Syrjanen, K, Hakama, M, Saarikoski, S, Vayrynen, M, Yliskoski, M, Syrjanen, S. Rodriguez, AC, Schiffman, M, Herrero, R, Wacholder, S, Hildesheim, A, Castle, PE. The Royal Society of Chemistry publishes 104 peer-reviewed journals that cover the core chemical sciences including related fields such as biology, biophysics, energy and environment, engineering, materials, medicine and physics. the site you are agreeing to our use of cookies. Couto, E, Saeterdal, I, Juvet, LK, Klemp, M. Di Mario, S, Basevi, V, Lopalco, PL, Balduzzi, S, D’Amico, R, Magrini, N. IARC . Will HPV vaccination prevent cervical cancer? 71 to 113; 1978 to 2020 How similar were the females in the trials to the target vaccination groups? Sharing links are not available for this article. For more information view the SAGE Journals Sharing page. I have read and accept the terms and conditions, View permissions information for this article. less than six months. Pollock, KG, Kavanagh, K, Potts, A, Love, J, Cuschieri, K, Cubie, H. Palmer, T, Wallace, L, Pollock, KG, Cuschieri, K, Robertson, C, Kavanagh, K. Neville, FG, McEachran, J, Aleman-Diaz, A, Whitehead, R, Cosma, A, Currie, D, National Statistics. Our journals range in scope from primary research to clinical practice. Previous title: Journal of the World Association for Emergency and Disaster Medicine (1985 - 1987) Access: Past Subscription. CIN in general is likely to have been overdiagnosed in the trials because cervical cytology was conducted at intervals of 6–12 months rather than at the normal screening interval of 36 months. Journal of the Royal Society of Medicine listed as JRSM Looking for abbreviations of JRSM? Although there is evidence that vaccination prevents cervical intraepithelial neoplasia grade 1 (CIN1) this is not a clinically important outcome (no treatment is given). Today, Barts and The London continues to uphold this commitment to pioneering medical education and research. JOURNAL OF THE ROYAL SOCIETY OF MEDICINE Volume 89 February 1996 The Clinical Section-a . If you have access to a journal via a society or association membership, please browse to your society journal, select an article to view, and follow the instructions in this box. Being firmly embedded within our east London community, and with an approach that is driven by the specific health needs of our diverse population, is what makes Barts and The London truly distinctive. In 1785, Sir William Blizard established England's first medical school, The London Hospital Medical College, to improve the health of east London's inhabitants. This product could help you, Accessing resources off campus can be a challenge. Villa, LL, Costa, RLR, Petta, CA, Andrade, RP, Ault, KA, Giuliano, AR. What should we do in the light of the uncertainty? Its continuous publication history dates back to 1809. The Royal Society of Medicine’s two journals, the Journal of the Royal Society of Medicine and JRSM Open, are outlets for scholarly comment and clinical research in the specialties of medicine and surgery. (DOI: 10.1177/0141076819899308) by Claire P Rees, Petra Brhlikova and Allyson M Pollock, will be published by the Journal of the Royal Society of Medicine at 00:05 hrs (UK time) on Wednesday 22 January 2020. Does HPV vaccine prevent pre-cancerous lesions? Please read and accept the terms and conditions and check the box to generate a sharing link. Published continuously since 1809, JRSM features scholarly comment and clinical research. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. SCImago Journal & Country Rank, Scopus Sources. Open access. JRSM is an independent scientific and educational publication, which features well-argued debate on important clinical topics and, although UK-based, has articles of interest and relevance to clinicians internationally. Members of _ can log in with their society credentials below, Claire P Rees, Petra Brhlikova, and Allyson M Pollock. The email address and/or password entered does not match our records, please check and try again. Carreon, JD, Sherman, ME, Guillen, D, Solomon, D, Herrero, R, Jeronimo, J. Peto, J, Gilham, C, Fletcher, O, Matthews, FE. There were 12 randomised control trials (RCTs) of Cervarix and Gardasil. Royal Society of Medicine1 Wimpole StreetLondonW1G 0AE+44 (0)20 7290 2900. The Journal of the Royal Society of Medicine is an open peer-reviewed medical journal. View or download all the content the society has access to. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. High efficacy against CIN1+ (CIN1, 2, 3 and adenocarcinoma in situ (AIS)) does not necessarily mean high efficacy against CIN3+ (CIN3 and AIS), which occurs much less frequently. Calling for women to still attend regular cervical screening, co-author of the study, Professor Allyson Pollock, of Newcastle University, said: “We have good evidence that cervical screening significantly reduces the risk of cervical cancer in women regardless of whether they have been vaccinated.”. Latest issues . For more information view the SAGE Journals Article Sharing page. January 22, 2020 expert reaction to study looking at the effectiveness of the HPV vaccine . Does HPV vaccine prevent cervical cancer? We found insufficient data to clearly conclude that HPV vaccine prevents the higher-grade abnormal cell changes that can eventually develop into cervical cancer.”, Dr Rees added: “Abnormal cell changes are likely to have been overdiagnosed in the trials because cervical cytology was conducted at 6-12 months rather than at the normal screening interval of 36 months. We provide authors with the option to make their article gold open access in any of our journals. All science: Open access research. Our journals; Search the journals; Royal Society Open Science. Smith, JS, Lindsay, L, Hoots, B, Keys, J, Franceschi, S, Winer, R. Kjaer, SK, Frederiksen, K, Munk, C, Iftner, T. Sow, PS, Watson-Jones, D, Kiviat, N, Changalucha, J, Mbaye, KD, Brown, J. Edited by Dr Kamran Abbasi, JRSM has been published continuously since 1809. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Linking ISSN (ISSN-L): 0141-0768. Romanowski, B, de Borba, PC, Naud, PS, Roteli-Martins, CM, De Carvalho, NS, Teixeira, JC. Publish with us. Scottish Cervical Screening Programme Statistics 2017/18. JRSM is editorially independent from the Royal Society of Medicine, and its editor is Dr Kamran Abbasi. It is the flagship journal of the Royal Society of Medicine with full editorial independence. A flurry of comments about the HPV vaccine have emerged this week, which is Cervical Cancer Prevention Week. 711–778 (December 2012) Volume 106, Issue 11. pp. Some society journals require you to create a personal profile, then activate your society account, You are adding the following journals to your email alerts, Did you struggle to get access to this article? Published by SAGE Publishing, the journals are editorially independent from the Royal Society of Medicine, and their editor is Dr Kamran Abbasi. The researchers also found that the trial populations had limited relevance and validity for real world settings. A growing selection of library products includes archives, data, case studies and video. We conducted a critical appraisal of published Phase 2 and 3 efficacy trials in relation to the prevention of cervical cancer in women. What is the risk of oncogenic HPV-type substitution? Paavonen, J, Naud, P, Salmeron, J, Wheeler, CM, Chow, SN, Apter, D. Lehtinen, M, Paavonen, J, Wheeler, CM, Jaisamrarn, U, Garland, SM, Castellsague, X. Wheeler, CM, Castellsague, X, Garland, SM, Szarewski, A, Paavonen, J, Naud, P. Palmroth, J, Merikukka, M, Paavonen, J, Apter, D, Eriksson, T, Natunen, K. Szarewski, A, Poppe, WAJ, Skinner, SR, Wheeler, CM, Paavonen, J, Naud, P. Apter, D, Wheeler, CM, Paavonen, J, Castellsague, X, Garland, SM, Skinner, SR. Struyf, F, Colau, B, Wheeler, CM, Naud, P, Garland, S, Quint, W. Herrero, R, Wacholder, S, Rodriguez, AC, Solomon, D, Gonzalez, P, Kreimer, AR. Since handing over a majority of our books list to Hodder, RSM Press are now pleased to hold a collection of carefully selected high quality publications. The flagship Journal of the Royal Society of Medicine (JRSM) is one of the most widely read and enjoyed general medical periodicals, providing insight into a broad spectrum of issues facing medical JOURNAL OF THE ROYAL SOCIETY OF MEDICINEVolume 96 April 2003 1 Lythe Brow Barn, Quernmore Road, Lancaster LA2 9LZ, UK E-mail: melaniefeldman@aol.com Downloaded from jrs.sagepub.com at PENNSYLVANIA STATE UNIV on March 5, 2014 The analysis, published by the Journal of the Royal Society of Medicine, assessed 12 published Phase 2 and 3 randomised controlled efficacy trials of the HPV vaccines Cervarix and Gardasil. Comment on “Will HPV vaccination prevent cervical cancer”. The e-mail addresses that you supply to use this service will not be used for any other purpose without your consent. SAGE is a leading international provider of innovative, high-quality content publishing more than 1000 journals and over 800 new books each year, spanning a wide range of subject areas. We use cookies to ensure that we give you the best possible experience on our website. Books. The flagship Journal of the Royal Society of Medicine (JRSM) is one of the most widely read and enjoyed general medical periodicals, providing insight into a broad spectrum of issues facing medical Together with St Bartholomew's Medical College, founded by John Abernethy in 1843 to help those living in the City of London, these two historic institutions are the bedrock of Barts and The London School of Medicine and Dentistry. Huh, WK, Joura, EA, Giuliano, AR, Iversen, OE, de Andrade, RP, Ault, KA. It is Journal of the Royal Society of Medicine. 639–710 (November 2012) Volume 106, Issue 10. pp. Contains open access . By continuing to browse the site you are agreeing to the use of cookies from the RSM. What is the evidence that vaccination prevents clinically meaningful HPV infection? Join the IPVS community and enjoy many membership benefits! Please check you selected the correct society from the list and entered the user name and password you use to log in to your society website. Leading the debate in clinical medicine. See. Brown, DR, Kjaer, SK, Sigurdsson, K, Iversen, OE, Hernandez-Avila, M, Wheeler, CM. Our local community offer to us a window to the world, ensuring that our ground-breaking research in cancer, cardiovascular and inflammatory diseases, and population health not only dramatically improves the outcomes for patients in London, but also has a far-reaching global impact. Methodological factors from the trials which may affect interpretation of the results. MEMBERSHIP . Jorgensen, L, Gotzsche, PC, Jefferson, T. Harper, DM, Franco, EL, Wheeler, C, Ferris, DG, Jenkins, D, Schuind, A. Harper, DM, Franco, EL, Wheeler, CM, Moscicki, AB, Romanowski, B, Roteli-Martins, CM. Transactions of the Royal Society of Tropical Medicine and Hygiene is an official journal of the Royal Society of Tropical Medicine and Hygiene. Advanced Search. How much information is there on long-term outcomes and how long does protection last? A systematic review of available evidence: efficacy of the two vaccines against HPV, Human papillomavirus vaccination – reasons for caution. Will HPV vaccination prevent cervical cancer? Transferred to Oxford University Press as of 2013; Explore journal content Latest issue Article collections All issues. IPVS members benefit from publication fees support in the P apillomavirus Research (PVR), the Journal of HPV and other Small DNA Tumor Viruses, official open access journal of IPVS. Metrics: SJR. While the researchers found evidence that vaccination prevents low grade abnormal cell changes, they said this is not clinically important because no treatment is given. Kreimer, AR, Rodriguez, AC, Hildesheim, A, Herrero, R, Porras, C, Schiffman, M. Rodriguez, AC, Solomon, D, Herrero, R, Hildesheim, A, Gonzalez, P, Wacholder, S. Hildesheim, A, Wacholder, S, Catteau, G, Struyf, F, Dubin, G, Herrero, R. Hildesheim, A, Gonzalez, P, Kreimer, AR, Wacholder, S, Schussler, J, Rodriguez, AC. The journal of the paper when published will be: https: //journals.sagepub.com/doi/full/10.1177/0141076819899308 WK, Joura, EA,,... Do in the light of the Royal Society of Medicine and Hygiene is official. Robin Fox who was editor for almost 10 years ; Explore journal content across... The journal of the HPV vaccine have emerged this week, which is cervical cancer raises doubts about vaccines. K, Iversen, OE, Hernandez-Avila, M, Wheeler, CM Hernandez-Avila M... Full-Text version of the options below to sign in or purchase access Phase 2 3! Medical journal or less, apart from one trial extension to just under nine years in Los Angeles,,... The lesions would have regressed spontaneously the London continues to uphold this commitment to pioneering medical education and research relate! 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